I have just finished writing vital and serious posts on 3 of Shakespeare's tragedies, each containing a different, original and illuminating view. (You are quite right: the trumpet-blowing bypass operation was not wholly successful). Sixth Form and first year university students of Othello, King Lear and Hamlet might like to take a look at my interpretations via the link to "Top Marks" on the right of this page.
There are many contenders for the accolade of best line and, although I would like to keep you in suspense for longer, I will now do the Big Reveal. Or - leave you to first have a guess. It's not even a whole line and consists of only 5 words.
No? Take your Complete Shakespeare and turn to Henry 1V pt 1 Act 111 scene i line vi. That looks a bit like algebra but please don't panic.
Hotspur: I have forgot the map.
There we have it: human, clear and resonating to all ages, races and sexes (actually only men forget the map).
The rebels against the King are planning who should have which bit of the kingdom when they have won the war. There is no 'if' about it to them - but they do need a map on which to draw the new boundaries. Our hot-headed daredevil thinks he has left it behind but Glendower, whom he derides, has brought it with him. Now they can quarrel.
This line is the perfect and ultimate proof that Shakespeare is timeless, (although Sat Nav has made such absent-mindedness less crucial). Nevertheless I reckon it is the one utterance that speaks to us all, always has done and always will.